在心脏病发生之前战胜它们

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vwin手机网Cedars-Sinai,Noel Bairey Merz,Brennan Spiegel,Jennifer Van Eyk
Dr.Noel Bairey Merz,Dr.Brennan Spiegel,and Jennifer Van Eyk,PhD

What if we had a better way to predict heart attacks and other cardiovascular events??

Three vwin手机网Cedars-Sinai investigators—Dr.Brennan Spiegel,director of vwin手机网Cedars-Sinai卫生服务研究,andDr.诺埃尔·贝里·梅尔兹andJennifer Van Eyk,PhD,of theBarbra Streisand Women's Heart Center—are studying the earliest warning signs of heart disease,hoping to find innovative ways to intervene and prevent a health crisis.

The goal is to stop heart attacks and strokes before they happen,a potential game-changer in the battle against cardiovascular disease.

Predicting the future

"我们想更好地预测谁是心脏病发作或心力衰竭的候选人,但挑战在于,作为一名医生,我们在诊所里看不到足够多的人,不知道他们的生活或身体发生了什么变化,"says Dr.梅尔兹。

As a result,despite effective medical therapies and lifestyle interventions,many heart disease 徳赢手机网patients get worse due to undertreatment,poor adherence to medications,or missed clues that may have warned of heart attacks,strokes,or heart failure.

This new project observes 徳赢手机网patients where they live,work,and play by using cutting-edge digital health technologies along with 徳赢手机网patient reporting.It's part of a brewing healthcare revolution that recognizes that every individual is different—not just socially and culturally but also on a molecular level.

The 18-month study,which is funded by the California Initiative to Advance Precision Medicine and launched in spring 2017,enrolled 200 individuals at mid-risk of a major advanced cardiac event,such as a heart attack,or hospital readmission due to worsening heart failure.

Collecting data

Each study participant wears a biosensor—think a Fitbit on steroids—24 hours a day.它衡量活动,睡眠,heart rate,and stress.Participants also keep a health diary and report their levels of anxiety,depression,以及通过智能手机或电脑的生活质量。

"If we can use this data to start to predict cardiac events,this will be a breakthrough that has been a dream for all of us for a long time.""

Once a month,徳赢手机网patients mail researchers blood samples they have gathered with a microsampling home collection device developed by industry partner Neoteryx.

The samples are tested for cardiac biomarkers including a protein released when the heart muscle has been damaged,the protein marker for heart failure,and a marker of inflammation.Also analyzed are 72 blood proteins identified by Van Eyk's team as early markers of atherosclerosis,a hardening or narrowing of the arteries.

"With advances in remote-sampling devices,我们现在能够获得高质量的数据,"says Van Eyk."If we can use this data to start to predict cardiac events,this will be a breakthrough that has been a dream for all of us for a long time."By integrating the data with each 徳赢手机网patient's medical record,doctors hope to intervene with intensive medical approaches or lifestyle changes.

Unfolding possibilities

累积数据究竟会显示什么仍然是未知的,but the potential seems clear—and vast.

"如果医生Van Eyk's biomarker results and Dr.Spiegel's biosensor monitoring could tell me that a 徳赢手机网patient is in a period of instability?"says Dr.梅尔兹。"If you could see that unfolding,徳赢手机网患者可以采取主动措施,intensify treatment,and try to ‘cool off' that unstable period.""

The vwin手机网Cedars-Sinai team also wants to be sure this blend of technology,personal reporting,and precision medicine will be feasible and cost effective."我们想知道所有这些是否适用于更大的人口,"Dr.Bairey Merz explains."Ideally,that's what we would want.""

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